PAX6 Antikörper (N-Term)
Kurzübersicht für PAX6 Antikörper (N-Term) (ABIN6940257)
Target
Alle PAX6 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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                                            Bindungsspezifität
- AA 1-300, N-Term
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                                            Spezifität
- Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters' anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
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                                            Aufreinigung
- Purified by Protein A/G
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                                            Immunogen
- Recombinant fragment (N-terminus, aa 1-300) of human PAX6 protein
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                                            Isotyp
- IgG1 kappa
 
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                                            Applikationshinweise
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                        Positive Control: Pancreas or Cerebellum. Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1 μg/mL), Optimal dilution for a specific application should be determined. 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Konzentration
- 200 μg/mL
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                                            Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Lagerung
- 4 °C,-80 °C
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                                            Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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                                            Haltbarkeit
- 24 months
 
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    - PAX6 (Paired Box 6 (PAX6))
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                                            Andere Bezeichnung
- PAX6
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                                            Molekulargewicht
- 47kDa
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                                            Gen-ID
- 5080
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                                            UniProt
- P26367
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                                            Pathways
- Peptide Hormone Metabolism, Carbohydrate Homeostasis
 Target
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