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Insulin Receptor Antikörper (Extracellular Domain)

Name: Insulin Receptor Antikörper (Extracellular Domain)
Brand: antibodies-online
SKU: ABIN6939799
Price: 663.89 EUR
Availability: InStock

INSR Reaktivität: Human ELISA, Coat Wirt: Maus Monoclonal INSR-1661 unconjugated

SDS-PAGE Analysis Purified Insulin Receptor Mouse Monoclonal Antibody (INSR/1661). (Insulin Receptor Antikörper (Extracellular Domain))

SDS

1 image

Produktnummer ABIN6939799

Datenblatt (PDF)

Target Alle Insulin Receptor (INSR) Antikörper anzeigen

Insulin Receptor (INSR)
Bindungsspezifität
16

14

13

10

8

8

8

5

5

4

4

4

4

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Extracellular Domain
Reaktivität
171

88

76

17

12

9

8

7

6

6

4

3

2

2

1

1

1

1

1

1

1

1
Human
Wirt
157

29

2

1
Maus
Passende Sekundärantikörper
Klonalität
146

43
Monoklonal
Konjugat
121

15

14

5

5

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser Insulin Receptor Antikörper ist unkonjugiert
Applikation
134

77

53

32

21

16

15

14

13

13

9

5

4

4

3

2

2

1

1

1

1

1

1

1
ELISA, Coating (Coat)

Aufreinigung

Purified by Protein A/G

Immunogen

Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

Klon

INSR-1661

Isotyp

IgG1 kappa

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Applikationshinweise

Positive Control: Jurkat cells. Human pancreas.
Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA)Optimal dilution for a specific application should be determined.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

200 μg/mL

Buffer

10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-80 °C

Informationen zur Lagerung

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit

24 months
Target

Insulin Receptor (INSR)

Andere Bezeichnung

INSR (INSR Produkte)

Hintergrund

The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

Molekulargewicht

135kDa

Gen-ID

3643

UniProt

P06213

Pathways

NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity