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FOXA1 Antikörper (AA 372-472)

Der Maus Monoklonal Anti-FOXA1-Antikörper wurde für WB, IHC, FACS, IF, ISt und StM validiert. Er ist geeignet, FOXA1 in Proben von Human zu detektieren.
Produktnummer ABIN6939651

Kurzübersicht für FOXA1 Antikörper (AA 372-472) (ABIN6939651)

Target

Alle FOXA1 Antikörper anzeigen
FOXA1 (Forkhead Box A1 (FOXA1))

Reaktivität

  • 169
  • 88
  • 39
  • 7
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 87
  • 82
  • 1
Maus

Klonalität

  • 112
  • 58
Monoklonal

Konjugat

  • 83
  • 10
  • 9
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FOXA1 Antikörper ist unkonjugiert

Applikation

  • 111
  • 91
  • 68
  • 63
  • 37
  • 36
  • 34
  • 21
  • 8
  • 8
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunostaining (ISt), Staining Methods (StM)

Klon

FOXA1-1512
  • Bindungsspezifität

    • 45
    • 33
    • 12
    • 9
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 372-472

    Keine Kreuzreaktivität

    Ratte (Rattus)

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    Recombinant human FOXA1 protein fragment (aa372-472) (exact sequence is proprietary)

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Positive Control: HepG-2 or MCF-7 cells. Liver, Pancreas, Bladder, Prostate, Colon and Lung and Breast.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    FOXA1 (Forkhead Box A1 (FOXA1))

    Andere Bezeichnung

    FOXA1

    Hintergrund

    The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors.HNF-1 (), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

    Molekulargewicht

    49kDa

    Gen-ID

    3169

    UniProt

    P55317

    Pathways

    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis
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