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HLA DQ Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch HLA DQ in FACS, IF, ELISA und Coat. Er zeigt eine Reaktivität gegenüber Human und Schwein.
Produktnummer ABIN6939632

Kurzübersicht für HLA DQ Antikörper (ABIN6939632)

Target

HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Reaktivität

  • 50
  • 34
  • 2
Human, Schwein

Wirt

  • 38
  • 14
Maus

Klonalität

  • 52
Monoklonal

Konjugat

  • 21
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Dieser HLA DQ Antikörper ist unkonjugiert

Applikation

  • 41
  • 32
  • 13
  • 12
  • 10
  • 8
  • 4
  • 3
  • 1
Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Coating (Coat)

Klon

SPM422
  • Spezifität

    Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    T4-positive CTL clone HG-38

    Isotyp

    IgG2a kappa
  • Applikationshinweise

    Positive Control: Raji cells. Tonsil or lymph node.

    Known Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

    Andere Bezeichnung

    HLA-DQ

    Molekulargewicht

    60kDa

    Gen-ID

    3117, 3118, 3119

    UniProt

    P01908, P01909, P01920
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