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HLA DQ Antikörper

HLA-DQ Reaktivität: Human, Schwein FACS, IF Wirt: Maus Monoclonal SPV-L3 unconjugated
Produktnummer ABIN6939631
  • Target Alle HLA DQ (HLA-DQ) Produkte
    HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
    Reaktivität
    • 31
    • 14
    • 2
    Human, Schwein
    Wirt
    • 29
    • 4
    Maus
    Klonalität
    • 33
    Monoklonal
    Konjugat
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA DQ Antikörper ist unkonjugiert
    Applikation
    • 31
    • 22
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    Flow Cytometry (FACS), Immunofluorescence (IF)
    Spezifität
    Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    T4-positive CTL clone HG-38
    Klon
    SPV-L3
    Isotyp
    IgG2a kappa
  • Applikationshinweise

    Positive Control: Raji cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
    Andere Bezeichnung
    HLA-DQ (HLA-DQ Produkte)
    Molekulargewicht
    60kDa
    Gen-ID
    3117, 3118, 3119
    UniProt
    P01908, P01909, P01920
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