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HLA DQ Antikörper

HLA-DQ Reaktivität: Human FACS, IF Wirt: Maus Monoclonal SPV-L3 unconjugated
Produktnummer ABIN6937405
  • Target Alle HLA DQ (HLA-DQ) Produkte
    HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
    Reaktivität
    • 31
    • 15
    • 2
    Human
    Wirt
    • 29
    • 4
    Maus
    Klonalität
    • 33
    Monoklonal
    Konjugat
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA DQ Antikörper ist unkonjugiert
    Applikation
    • 31
    • 22
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    Flow Cytometry (FACS), Immunofluorescence (IF)
    Spezifität
    Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
    Kreuzreaktivität (Details)
    Human. Pig.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    T4-positive CTL clone HG-38
    Klon
    SPV-L3
    Isotyp
    IgG2a kappa
  • Applikationshinweise

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

    Positive_Control: Raji cells. Tonsil or lymph node.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
    Andere Bezeichnung
    HLA-DQ (HLA-DQ Produkte)
    Hintergrund
    CELIAC1, DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE), HLA Class II DQ, HLA class II histocompatibility antigen DQ, HLA class II histocompatibility antigen DQ(1) alpha chain, HLA class II histocompatibility antigen DQ(3) alpha chain, HLA DQA1, HLA DQB, HLA DQB1, IDDM1, Leucocyte antigen DQA1, Major histocompatibility complex class II DQ alpha 1, Major histocompatibility complex class II DQ beta 1, MHC class II antigen HLA DQ beta 1, MHC class II HLA DQ alpha 1, MHC class II HLA DQ beta glycoprotein, MHC DQ beta,HLA-DQ (MHC II)
    Cellular localisation: Cell surface
    Molekulargewicht
    60kDa
    Gen-ID
    3117, 3118, 3119
    UniProt
    P01908, P01909, P01920
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