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HLA-A Antikörper

HLA-A Reaktivität: Human FACS, IF Wirt: Maus Monoclonal 108-2C5 unconjugated
Produktnummer ABIN6939619
  • Target Alle HLA-A Antikörper anzeigen
    HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))
    Reaktivität
    • 75
    • 15
    • 6
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 49
    • 33
    • 3
    Maus
    Klonalität
    • 51
    • 34
    Monoklonal
    Konjugat
    • 42
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-A Antikörper ist unkonjugiert
    Applikation
    • 46
    • 45
    • 28
    • 23
    • 20
    • 13
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF)
    Spezifität
    HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the 1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the alpha1 domain was demonstrated in the formation of an intralocus HLA-A determinant.
    Immunogen
    Normal human peripheral blood lymphocytes
    Klon
    108-2C5
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product HLA-A Primärantikörper
  • Applikationshinweise

    Positive Control: Raji, THP-1 and Jurkat cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))
    Andere Bezeichnung
    HLA-A (HLA-A Produkte)
    Synonyme
    HLAA antikoerper, major histocompatibility complex, class I, A antikoerper, HLA-A antikoerper
    Molekulargewicht
    ~41kDa
    Gen-ID
    3105
    UniProt
    P01889, P30443, P30499
    Pathways
    T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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