GZMB Antikörper (AA 73-187)

Produktnummer ABIN6939591

Dieses Anti-GZMB-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von GZMB in WB, IHC und StM. Geeignet für Human.

Kurzübersicht für GZMB Antikörper (AA 73-187) (ABIN6939591)

Target: GZMB (Granzyme B (GZMB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GZMB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)

Klon: GZMB-3014

Produktdetails anti-GZMB Antikörper

Bindungsspezifität: AA 73-187

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: A431 cells. Human tonsil, spleen or Hodgkin's Lymphoma tissue (IHC).

Known Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Andere Bezeichnung: GZMB

Hintergrund: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.

Molekulargewicht: 29-32kDa

Gen-ID: 3002

UniProt: P10144

Pathways: Apoptose, Caspase Kaskade in der Apoptose