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EGFR Antikörper

Name: EGFR Antikörper
Brand: antibodies-online
SKU: ABIN6939289
Price: 617.42 EUR
Availability: InStock

EGFR Reaktivität: Human FACS, IP, AP, ProA, in vivo, Act Wirt: Maus Monoclonal B1D8 unconjugated

SDS-PAGE Analysis Purified EGFR Mouse Monoclonal Antibody (B1D8). (EGFR Antikörper)

SDS

1 image

Produktnummer ABIN6939289

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Reaktivität
762

299

287

25

25

24

20

14

8

3

2

2

1

1

1

1

1

1
Human
Wirt
581

178

14

13

5

4

1

1
Maus
Passende Sekundärantikörper
Klonalität
543

249

2
Monoklonal
Konjugat
416

58

29

22

20

18

18

17

16

16

16

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
539

254

151

151

129

102

98

93

82

48

37

34

34

19

10

8

6

5

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Affinity Purification (AP), Proliferation Assay (ProA), In vivo Studies (in vivo), Activation (Act)

Spezifität

This antibody reacts with the extracellular domain of EGFR and blocks the EGF/TGF'induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

Keine Kreuzreaktivität

Maus, Ratte (Rattus)

Aufreinigung

Purified by Protein A/G

Immunogen

Microsomes from A431 cells.

Klon

B1D8

Isotyp

IgG2a kappa

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EGFR Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibody
EGFR Reaktivität: Human, Ratte WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Positive Control: A431 cells, Breast or Bladder cancer.
Known Application: Affinity Purification (For coupling, order Ab without BSA), Blocks Ligand-induced Activation of EGFR, Inhibits Proliferation of A431 Cells (Order Ab without sodium azide), Arrests Tumor Growth in vivo (Order Ab without BSA &Azide), Immunoprecipitation (1-2 μg/500 μg protein lysate), Flow Cytometry (0.5-1 μg/million cells), Optimal dilution for a specific application should be determined.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

200 μg/mL

Buffer

10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-80 °C

Informationen zur Lagerung

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit

24 months
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR (EGFR Produkte)

Molekulargewicht

~170kDa (wild type) and ~145kDa (vIII variant)

Gen-ID

1956

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine