STAT2 Antikörper

Produktnummer ABIN6938459

Dieser Maus Monoklonal Antikörper detektiert spezifisch STAT2 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für STAT2 Antikörper (ABIN6938459)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAT2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: STAT2-2650

Produktdetails anti-STAT2 Antikörper

Verwendungszweck: STAT2 Antibody

Spezifität: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN- is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human STAT2 protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Ramos and Jurkat cell lysates. HeLa cell extract. Human lung carcinoma tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Andere Bezeichnung: STAT2

Hintergrund:

Homo sapiens interferon alpha induced transcriptional activator, interferon alpha induced transcriptional activator (ISGF3), P113, signal transducer and activator of transcription 2 113kD (STAT113), Signal transducer and activator of transcription 2 (STAT2)

Ramos and Jurkat cell lysates. HeLa cell extract. Human lung carcinoma tissue.

Molekulargewicht: 113kDa

Gen-ID: 6773, 530595

UniProt: P52630

Pathways: JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events