SPTAN1 Antikörper (AA 2351-2475)

Produktnummer ABIN6938440

Produktdetails anti-SPTAN1 Antikörper

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Bindungsspezifität: AA 2351-2475

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SPTAN1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous and chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin I and spectrin I are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II, a neuronal cytoskeleton protein.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human SPTAN1 protein (around aa 2351-2475) (exact sequence is proprietary)

Klon: SPTAN1-3351

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human colon or kidney tissues (IHC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Andere Bezeichnung: SPTAN1 (SPTAN1 Produkte)

Synonyme: im:7157190 antikoerper, wu:fa20e05 antikoerper, wu:fb33g08 antikoerper, wu:fk32a10 antikoerper, zgc:112229 antikoerper, 2610027H02Rik antikoerper, Spna-2 antikoerper, Spna2 antikoerper, EIEE5 antikoerper, NEAS antikoerper, SPTA2 antikoerper, A2a antikoerper, IPF antikoerper, SPECA antikoerper, spectrin alpha, non-erythrocytic 1 antikoerper, spectrin, alpha, non-erythrocytic 1 antikoerper, SPTAN1 antikoerper, sptan1 antikoerper, Sptan1 antikoerper

Hintergrund: Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2,Fodrin / Alpha Spectrin II (SPTAN1) / NEAS
Cellular localisation: Cytoplasm

Molekulargewicht: 240kDa

Gen-ID: 6709, 372331

UniProt: Q13813

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization