Rekombinanter MMP3 Antikörper (AA 317-327)

Produktnummer ABIN6937884

Der Kaninchen Monoklonal Anti-MMP3-Antikörper wurde für WB, ELISA, FACS und Coat validiert. Er ist geeignet, MMP3 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter MMP3 Antikörper (AA 317-327) (ABIN6937884)

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MMP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Coating (Coat)

Klon: MMP3-1994R

Produktdetails anti-MMP3 Antikörper

Bindungsspezifität: AA 317-327

Spezifität: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 317-327) of human MMP3 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (1-2 μg/million cells), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Human prostate or lung tissue. A-431 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu MMP3

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Andere Bezeichnung: MMP3

Hintergrund: CHDS6, Matrix metalloproteinase 3, Matrix metalloproteinase-3, MGC126102, MGC126103, MGC126104, MMP 3, MMP-3, MMP3, Proteoglycanase, SL-1, SL1, STMY, STMY1, STR1, Stromelysin 1, Stromelysin-1, Transin 1,MMP3 (Marker of Metastasis and Rheumatoid Arthritis)
Cellular localisation: Cytoplasm, extracellular matrix

Molekulargewicht: 57kDa

Gen-ID: 4314, 375129

UniProt: P08254