MCM7 Antikörper (AA 195-319)
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- Target Alle MCM7 Antikörper anzeigen
- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
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Bindungsspezifität
- AA 195-319
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MCM7 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human MCM7 protein fragment (aa195-319) (exact sequence is proprietary)
- Klon
- MCM7-1467
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product MCM7 Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: MCF-7, HEK293, A549, Raji or Ramos cells. Tonsil.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
- Andere Bezeichnung
- MCM7 (MCM7 Produkte)
- Synonyme
- CDC47 antikoerper, MCM2 antikoerper, P1.1-MCM3 antikoerper, P1CDC47 antikoerper, P85MCM antikoerper, PNAS146 antikoerper, MCM7 antikoerper, AI747533 antikoerper, Mcmd7 antikoerper, mCDC47 antikoerper, chunp6911 antikoerper, nyz175 antikoerper, sr:nyz175 antikoerper, cdc47 antikoerper, cdc47-2 antikoerper, mcm7 antikoerper, xmcm7 antikoerper, CG4978 antikoerper, DmMCM7 antikoerper, DmeMCM7 antikoerper, Dmel\\CG4978 antikoerper, McM7 antikoerper, Mcp-PCR1 antikoerper, PCR1 antikoerper, anon-EST:Liang-1.66 antikoerper, clone 1.66 antikoerper, minichromosome maintenance complex component 7 antikoerper, mini-chromosome maintenance complex protein 7 antikoerper, minichromosome maintenance complex component 2 antikoerper, minichromosome maintenance complex component 7 L homeolog antikoerper, Minichromosome maintenance 7 antikoerper, minichromosome maintenance complex component 7 S homeolog antikoerper, MCM complex subunit Mcm7 antikoerper, MCM7 antikoerper, CDC47 antikoerper, Mcm7 antikoerper, MCM2 antikoerper, mcm7 antikoerper, mcm7.L antikoerper, mcm7.S antikoerper
- Hintergrund
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CDC47, DNA replication licensing factor MCM7, MCM7 mini chromosome maintenance deficient 7, Mini chromosome Maintenance 7, Mini chromosome maintenance protein 7, P1.1-MCM3, P1CDC47, P85MCM, PNAS146,MCM7 (Proliferation Marker)
Cellular localisation: Nuclear - Molekulargewicht
- 88kDa
- Gen-ID
- 4176, 438720
- UniProt
- P33993
- Pathways
- DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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