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Insulin Receptor Antikörper (Extracellular Domain)

INSR Reaktivität: Human ELISA, Coat Wirt: Maus Monoclonal INSR-1661 unconjugated

Produktnummer ABIN6937574

Datenblatt (PDF)

Target Alle Insulin Receptor (INSR) Antikörper anzeigen

Insulin Receptor (INSR)
Bindungsspezifität
16

14

13

10

8

8

8

5

5

4

4

4

4

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Extracellular Domain
Reaktivität
171

88

76

17

12

9

8

7

6

6

4

3

2

2

1

1

1

1

1

1

1

1
Human
Wirt
157

29

2

1
Maus
Passende Sekundärantikörper
Klonalität
146

43
Monoklonal
Konjugat
121

15

14

5

5

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser Insulin Receptor Antikörper ist unkonjugiert
Applikation
134

77

53

32

21

16

15

14

13

13

9

5

4

4

3

2

2

1

1

1

1

1

1

1
ELISA, Coating (Coat)

Spezifität

The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

Kreuzreaktivität (Details)

Human.

Aufreinigung

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen

Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

Klon

INSR-1661

Isotyp

IgG1 kappa

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INSR Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB50340 unconjugated

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INSR Reaktivität: Human IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 51-150) antibody
INSR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 27-57), (N-Term) antibody
INSR Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB1421 unconjugated

Applikationshinweise

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA)Optimal dilution for a specific application should be determined.
Positive_Control: Jurkat cells. Human pancreas.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel

Azide free

Lagerung

-20 °C,-80 °C

Informationen zur Lagerung

Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit

24 months
Target

Insulin Receptor (INSR)

Andere Bezeichnung

INSR (INSR Produkte)

Hintergrund

CD220, HHF5, HINSR A, INSR, Insulin receptor, Insulin receptor subunit alpha, INSR,Insulin Receptor Alpha
Cellular localisation: Cytoplasm.

Molekulargewicht

135kDa

Gen-ID

3643, 465744

UniProt

P06213

Pathways

NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity