ICOSLG Antikörper (AA 23-149)
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- Target Alle ICOSLG Antikörper anzeigen
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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Bindungsspezifität
- AA 23-149
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser ICOSLG Antikörper ist unkonjugiert
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Applikation
- ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
- Klon
- ICOSL-3260
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product ICOSLG Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HL60, HuT78 and HUVEC cells. Prostate or Colon Carcinoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
- Andere Bezeichnung
- ICOSLG (ICOSLG Produkte)
- Synonyme
- ICOSLG antikoerper, AU044799 antikoerper, B7-H2 antikoerper, B7RP-1 antikoerper, B7h antikoerper, BG071784 antikoerper, GI50 antikoerper, GL50 antikoerper, GL50-B antikoerper, ICOS-L antikoerper, Icoslg antikoerper, LICOS antikoerper, Ly115l antikoerper, mKIAA0653 antikoerper, B7H2 antikoerper, B7RP1 antikoerper, CD275 antikoerper, ICOSL antikoerper, Icosl antikoerper, RGD1562791 antikoerper, inducible T-cell costimulator ligand antikoerper, icos ligand antikoerper, inducible T-cell co-stimulator ligand antikoerper, ICOSLG antikoerper, Icosl antikoerper, Icoslg antikoerper
- Hintergrund
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B7 homolog 2 (B7H2), B7 like protein Gl50, B7 related protein 1 (B7RP1), CD275, CD275 antigen, GL50, ICOS LG, ICOS ligand (ICOSL), Inducible T cell co stimulator ligand, LICOS, Transmembrane protein B7 H2 ICOS ligand,ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target)
Cellular localisation: Cell Surface - Molekulargewicht
- 36kDa
- Gen-ID
- 23308, 14155
- UniProt
- O75144
- Pathways
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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