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Rekombinanter HLA DQ Antikörper

Der Maus Monoklonal Anti-HLA DQ-Antikörper wurde für FACS, IF und IHC (fro) validiert. Er ist geeignet, HLA DQ in Proben von Human zu detektieren.
Produktnummer ABIN6937407

Kurzübersicht für Rekombinanter HLA DQ Antikörper (ABIN6937407)

Target

HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 50
  • 35
  • 2
Human

Wirt

  • 38
  • 14
Maus

Klonalität

  • 52
Monoklonal

Konjugat

  • 21
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Dieser HLA DQ Antikörper ist unkonjugiert

Applikation

  • 41
  • 32
  • 13
  • 12
  • 10
  • 7
  • 5
  • 3
  • 2
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon

RSPV-L3
  • Spezifität

    Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.

    Kreuzreaktivität (Details)

    Human. Pig.

    Aufreinigung

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    T4-positive CTL clone HG-38

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Frozen only) (1-2 μg/mL for 30 minutes at RT)Optimal dilution for a specific application should be determined.

    Positive_Control: Raji cells. Tonsil or lymph node.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Konservierungsmittel

    Azide free

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Haltbarkeit

    24 months
  • Target

    HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

    Andere Bezeichnung

    HLA-DQ

    Hintergrund

    CELIAC1, DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE), HLA class II histocompatibility antigen DQ(1) alpha chain, HLA class II histocompatibility antigen DQ(3) alpha chain, IDDM1, Leucocyte antigen DQA1, Major histocompatibility complex class II DQ alpha 1 (HLA DQA1), Major histocompatibility complex class II DQ beta 1 (HLA DQB1), MHC class II antigen HLA DQ beta 1, MHC class II HLA DQ alpha 1, MHC class II HLA DQ beta glycoprotein,HLA-DQ (MHC II)
    Cellular localisation: Cell Surface

    Molekulargewicht

    60kDa

    Gen-ID

    3117, 3118, 3119

    UniProt

    P01908, P01909, P01920
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