Gelsolin Antikörper

Produktnummer ABIN6937348

Der Maus Monoklonal anti-Gelsolin Antikörper (Klon CPTC-Gelsolin-1) (ABIN6937348) detektiert spezifisch Gelsolin in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Gelsolin Antikörper (ABIN6937348)

Target: Gelsolin (GSN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Gelsolin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: CPTC-Gelsolin-1

Produktdetails anti-Gelsolin Antikörper

Spezifität: Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-length protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: MCF cell lysate, Tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Gelsolin

Target: Gelsolin (GSN)

Andere Bezeichnung: GSN

Hintergrund: Actin depolymerizing factor, ADF, AGEL, Brevin, Gsn,Gelsolin / Actin-depolymerizing Factor
Cellular localisation: Cytoplasm and secreted

Molekulargewicht: 90kDa

Gen-ID: 2934, 522373

UniProt: P06396

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie