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EGFR Antikörper

EGFR Reaktivität: Human FACS, IP, AP, ProA, in vivo, Act Wirt: Maus Monoclonal B1D8 unconjugated

Produktnummer ABIN6937132

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Reaktivität
762

299

287

25

25

24

20

14

8

3

2

2

1

1

1

1

1

1
Human
Wirt
581

178

14

13

5

4

1

1
Maus
Passende Sekundärantikörper
Klonalität
543

249

2
Monoklonal
Konjugat
416

58

29

22

20

18

18

17

16

16

16

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
539

254

151

151

129

102

98

93

82

48

37

34

34

19

10

8

6

5

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Affinity Purification (AP), Proliferation Assay (ProA), In vivo Studies (in vivo), Activation (Act)

Spezifität

This antibody reacts with the extracellular domain of EGFR and blocks the EGF/TGF'induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

Keine Kreuzreaktivität

Maus, Ratte (Rattus)

Kreuzreaktivität (Details)

Human. Does not react with Mouse or Rat.

Aufreinigung

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen

Microsomes from A431 cells.

Klon

B1D8

Isotyp

IgG2a kappa

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EGFR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (pSer695) antibody
EGFR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 1021-1210) antibody
EGFR Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibody
EGFR Reaktivität: Human, Ratte WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Known_Application: Affinity Purification (For coupling, order Ab without BSA), Blocks Ligand-induced Activation of EGFR, Inhibits Proliferation of A431 cells (Order Ab without sodium azide), Arrests Tumor Growth in vivo (Order Ab without BSA &Azide), Immunoprecipitation (1-2 μg/500 μg protein lysate), Flow Cytometry (1-2 μg/million cells), Optimal dilution for a specific application should be determined.
Positive_Control: A431 cells, Breast or Bladder cancer.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel

Azide free

Lagerung

-20 °C,-80 °C

Informationen zur Lagerung

Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit

24 months
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR (EGFR Produkte)

Hintergrund

Erbb1, ERBB1, Errp, HER1, mENA, PIG61, Proto-oncogene c-ErbB-1, Receptor Tyrosine Protein Kinase, ErbB1, Urogastrone, wa2, Wa5,EGFR (Epidermal Growth Factor Receptor)
Cellular localisation: Cell surface

Molekulargewicht

~170kDa (wild type) and ~145kDa (vIII variant)

Gen-ID

1956, 488293

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine