EGFR Antikörper (Extracellular Domain)
Kurzübersicht für EGFR Antikörper (Extracellular Domain) (ABIN6937131)
Target
Alle EGFR Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- Extracellular Domain
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Verwendungszweck
- EGFR (Epidermal Growth Factor Receptor) Antibody
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Spezifität
- This MAb recognizes a protein of 170 kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
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Keine Kreuzreaktivität
- Maus
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Kreuzreaktivität (Details)
- Human. Does not react with Mouse.
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Aufreinigung
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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Immunogen
- Recombinant extracellular domain of human EGFR protein
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Isotyp
- IgG2a
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anti-Epidermal Growth Factor Receptor (EGFR) (AA 693-893) antibody
EGFR Reaktivität: Human WB, IHC, ELISA, FACS Wirt: Maus Monoclonal 7A6F12 unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (AA 693-893) antibodyEGFR Reaktivität: Human WB, IHC, ELISA, FACS Wirt: Maus Monoclonal 5G9B5 unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (AA 693-893), (Mutant) antibodyEGFR Reaktivität: Human IHC, ELISA, FACS Wirt: Maus Monoclonal 5G9B5 unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (AA 888-1210) antibodyEGFR Reaktivität: Human WB, IHC Wirt: Maus Monoclonal C4 unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (AA 1163-1191), (C-Term) antibodyEGFR Reaktivität: Human WB, IHC (p) Wirt: Maus Monoclonal 688CT33-1-3 unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (AA 693-893) antibodyEGFR Reaktivität: Human WB, ELISA, FACS Wirt: Maus Monoclonal 5E10D3 unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibodyEGFR Reaktivität: Human, Maus, Ratte, Affe, Schwein, Rind (Kuh), Huhn, Hund, Pferd, Kaninchen, Meerschweinchen, Avian, Cat, Esel, Ziege, Hamster, Schaf WB, IHC (p), IHC (fro) Wirt: Ziege Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) antibodyKD Validated EGFR Reaktivität: Human WB, FACS, IF (p) Wirt: Kaninchen Monoclonal 24GB4395 unconjugated Recombinant Antibody
anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibodyEGFR Reaktivität: Human, Ratte WB, IHC, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor (EGFR) (AA 344-492) antibodyEGFR Reaktivität: Human WB, IHC Wirt: Maus Monoclonal GFR-2341 unconjugated
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Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: A431 cells, Breast or Bladder cancer.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1.0 mg/mL
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Buffer
- Prepared in 10 mM PBS
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Konservierungsmittel
- Azide free
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Haltbarkeit
- 24 months
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- EGFR (Epidermal Growth Factor Receptor (EGFR))
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Andere Bezeichnung
- EGFR
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Hintergrund
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Erbb1, ERBB1, Errp, HER1, mENA, PIG61, Proto-oncogene c-ErbB-1, Receptor Tyrosine Protein Kinase, ErbB1, Urogastrone, wa2, Wa5
A431 cells
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Molekulargewicht
- ~170kDa (wild type) and ~145kDa (vIII variant)
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Gen-ID
- 1956, 488293
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UniProt
- P00533
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Pathways
- NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine
Target
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