CD79a Antikörper (AA 202-216)
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- Target Alle CD79a (CD79A) Antikörper anzeigen
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
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Bindungsspezifität
- AA 202-216
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD79a Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
- Kreuzreaktivität (Details)
- Human. Monkey. Pig. Cow. Mouse. Rat.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- A synthetic peptide corresponding to aa 202-216 (GTYQDVGSLNIADVQ) of human CD79a protein (JCB117 and HM47/A9).
- Klon
- JCB117-HM47-A9
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product CD79A Primärantikörper
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- Applikationshinweise
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Known_Application: Western Blot (1-2 μg/mL), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Raji, Daudi or Ramos cells. Germinal center B- cells in a lymph node or tonsil.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
- Andere Bezeichnung
- CD79A (CD79A Produkte)
- Synonyme
- CD79A antikoerper, Ig-alpha antikoerper, Iga antikoerper, Igalpha antikoerper, Ly-54 antikoerper, Ly54 antikoerper, mb-1 antikoerper, IGA antikoerper, MB-1 antikoerper, IG-alpha antikoerper, CD79a molecule antikoerper, CD79A antigen (immunoglobulin-associated alpha) antikoerper, Cd79a molecule-like antikoerper, CD79A antikoerper, Cd79a antikoerper, Cd79al antikoerper
- Hintergrund
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B lymphocyte-specific MB1 protein, B-cell antigen receptor complex-associated protein alpha chain, CD79a molecule immunoglobulin associated alpha, Ig-alpha, IGA, IgM-alpha, Immunoglobulin-associated alpha, Ly54, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein,CD79a (B Cell Marker)
Cellular localisation: Cell Surface - Molekulargewicht
- 44kDa
- Gen-ID
- 973, 631567
- UniProt
- P11912
- Pathways
- BCR Signaling
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