CD46 Antikörper

Produktnummer ABIN6936735

Der Maus Monoklonal anti-CD46 Antikörper wird verwendet zum Nachweis von CD46 in Proben von Human und Pavian. Er wurde validiert für FACS und IF.

Kurzübersicht für CD46 Antikörper (ABIN6936735)

Target: CD46

Reaktivität: Human, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: 169-1-E4-3

Produktdetails anti-CD46 Antikörper

Verwendungszweck: CD46 (Membrane Cofactor Protein) Antibody

Spezifität: Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Keine Kreuzreaktivität: Pferd

Kreuzreaktivität (Details): Human. Baboon. Does not react with Horse.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate.

Immunogen: Stimulated human leukocytes

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: K562, U937, HL60, HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46

Hintergrund:

AHUS2, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen, Trophoblast lymphocyte cross reactive antigen

HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil., HL60, K562, U937

Molekulargewicht: 52-58kDa

Gen-ID: 4179, 510402

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization