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CD46 Antikörper

CD46 Reaktivität: Human FACS, IF Wirt: Maus Monoclonal 169-1-E4-3 unconjugated

Produktnummer ABIN6936735

Datenblatt (PDF)

Target Alle CD46 Antikörper anzeigen

CD46
Reaktivität
122

34

20

10

10

3
Human
Wirt
80

59

2

1
Maus
Passende Sekundärantikörper
Klonalität
72

70
Monoklonal
Konjugat
55

14

14

10

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser CD46 Antikörper ist unkonjugiert
Applikation
83

82

37

37

28

17

14

14

13

9

7

5

5

2

2

1

1

1

1
Flow Cytometry (FACS), Immunofluorescence (IF)

Spezifität

Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Keine Kreuzreaktivität

Pferd

Kreuzreaktivität (Details)

Human. Baboon. Does not react with Horse.

Aufreinigung

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen

Stimulated human leukocytes

Klon

169-1-E4-3

Isotyp

IgG2a kappa

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CD46 Reaktivität: Human WB, FACS, IF, IHC (p) Wirt: Kaninchen Polyclonal RB21743 unconjugated

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CD46 Reaktivität: Human, Rind (Kuh) WB, FACS, IP Wirt: Maus Monoclonal MEM-258 Biotin

anti-CD46 (CD46) antibody (FITC)
CD46 Reaktivität: Human, Rind (Kuh) FACS Wirt: Maus Monoclonal MEM-258 FITC

Applikationshinweise

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: K562, U937, HL60, HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel

Azide free

Lagerung

-20 °C,-80 °C

Informationen zur Lagerung

Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit

24 months
Target

CD46

Andere Bezeichnung

CD46 (CD46 Produkte)

Hintergrund

AHUS2, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen, Trophoblast lymphocyte cross reactive antigen,CD46 (Membrane Cofactor Protein)
Cellular localisation: Cell Surface

Molekulargewicht

52-58kDa

Gen-ID

4179, 510402

UniProt

P15529

Pathways

Regulation of Actin Filament Polymerization