CA8 Antikörper
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- Target Alle CA8 Antikörper anzeigen
- CA8 (Carbonic Anhydrase VIII (CA8))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CA8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human CA8 protein
- Klon
- CPTC-CA8-2
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product CA8 Primärantikörper
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- Applikationshinweise
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human cerebellum. Selective expression in purkinje cells. HEK-293 or K-562 cell lines.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- CA8 (Carbonic Anhydrase VIII (CA8))
- Andere Bezeichnung
- CA8 (CA8 Produkte)
- Synonyme
- AW546993 antikoerper, Ca8 antikoerper, Cals antikoerper, Cals1 antikoerper, Carp antikoerper, wdl antikoerper, zgc:110118 antikoerper, CA-VIII antikoerper, CALS antikoerper, CAMRQ3 antikoerper, CARP antikoerper, carbonic anhydrase 8 antikoerper, carbonic anhydrase VIII antikoerper, CAH8 antikoerper, Car8 antikoerper, ca8 antikoerper, CA8 antikoerper
- Hintergrund
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CA-VIII, CALS, CARP, MGC120502, MGC99509,Carbonic Anhydrase VIII
Cellular localisation: Cytoplasm. Cell surface. - Molekulargewicht
- 32.97kDa
- Gen-ID
- 767, 654388
- UniProt
- P35219
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