MAPT Antikörper (pSer202, pThr205) (PE)

Produktnummer ABIN6932906

Der PE-konjugierte Kaninchen Monoklonal anti-MAPT Antikörper (Klon AH36) (ABIN6932906) detektiert spezifisch MAPT in WB, ELISA, IHC, IF, ICC und DB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MAPT Antikörper (pSer202, pThr205) (PE) (ABIN6932906)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MAPT Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Dot Blot (DB)

Klon: AH36

Produktdetails anti-MAPT Antikörper (PE)

Bindungsspezifität: pSer202, pThr205

Spezifität: Expressed in neurons.,Detects ~79 kDa.

Kreuzreaktivität: Human, Maus

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide of Human Phospho Tau (Ser202/Thr205)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

• WB (1:500)
• ICC/IF (1:500)
• IHC (1:500)
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:500 dilution of ABIN6932906 was sufficient for detection of Tau in 10 μg Baculovirus by dot blot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: Tau

Hintergrund: Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3).

Gen-ID: 4137

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size