TANK Antikörper (AA 151-260) (Biotin)

Produktnummer ABIN685359

Dieses Anti-TANK-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TANK in ELISA, IHC (p) und IHC (fro). Geeignet für Human.

Kurzübersicht für TANK Antikörper (AA 151-260) (Biotin) (ABIN685359)

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TANK Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TANK Antikörper (Biotin)

Bindungsspezifität: AA 151-260

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TANK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TANK

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Andere Bezeichnung: TANK

Hintergrund:

Synonyms: I TRAF, ITRAF, TRAF family member associated NF KAPPA B activator, TRAF family member associated NFKB activator, TRAF interacting protein, TRAF interacting protein TANK isoform a, I-TRAF, Tank, TANK_HUMAN, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF interacting protein TANK isoform b, TRAF2.

Background: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, this protein can block TRAF2 binding to LMP1, the Epstein Barr virus transforming protein, and inhibit LMP1-mediated NF kappa B activation.

Gen-ID: 10010

Pathways: p53 Signalweg, TLR Signalweg, Activation of Innate immune Response