TANK Antikörper (AA 151-260)
Kurzübersicht für TANK Antikörper (AA 151-260) (ABIN685357)
Target
Alle TANK Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 151-260
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Homologie
- Human,Mouse,Rat
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human TANK
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Isotyp
- IgG
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Applikationshinweise
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Haltbarkeit
- 12 months
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- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
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Andere Bezeichnung
- TANK
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Hintergrund
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Synonyms: I TRAF, ITRAF, TRAF family member associated NF KAPPA B activator, TRAF family member associated NFKB activator, TRAF interacting protein, TRAF interacting protein TANK isoform a, I-TRAF, Tank, TANK_HUMAN, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF interacting protein TANK isoform b, TRAF2.
Background: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, this protein can block TRAF2 binding to LMP1, the Epstein Barr virus transforming protein, and inhibit LMP1-mediated NF kappa B activation.
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Gen-ID
- 10010
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Pathways
- p53 Signalweg, TLR Signalweg, Activation of Innate immune Response
Target
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