DKK1 Antikörper (AA 201-266) (HRP)

Produktnummer ABIN678167

Produktdetails anti-DKK1 Antikörper (HRP)

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Bindungsspezifität: AA 201-266

Reaktivität: Human, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DKK1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Hund, Human

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DKK1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-DKK1 Antikörper (HRP) (ABIN678167)

Pontremoli, Brioschi, Baetta, Ghilardi, Banfi: "Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells." in: Scientific reports, Vol. 8, Issue 1, pp. 16671, (2018) (PubMed).

Details zu DKK1

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Andere Bezeichnung: DKK1 (DKK1 Produkte)

Synonyme: DKK-1 antikoerper, SK antikoerper, AI414495 antikoerper, SGY antikoerper, SGY-1 antikoerper, SGY1 antikoerper, Soggy antikoerper, mSgy antikoerper, dkk1 antikoerper, dkk antikoerper, dkk-1 antikoerper, xdkk1 antikoerper, Xdkk-1 antikoerper, Dickkopf1 antikoerper, dickkopf-1 antikoerper, mdkk-1 antikoerper, dkk1-A antikoerper, dickkopf WNT signaling pathway inhibitor 1 antikoerper, dickkopf like acrosomal protein 1 antikoerper, dickkopf-related protein 1 antikoerper, dickkopf-like 1 antikoerper, dickkopf WNT signaling pathway inhibitor 1b antikoerper, dickkopf protein antikoerper, dickkopf WNT signaling pathway inhibitor 1 S homeolog antikoerper, DKK1 antikoerper, Dkk1 antikoerper, DKKL1 antikoerper, LOC100228789 antikoerper, Dkkl1 antikoerper, dkk1b antikoerper, dkk1 antikoerper, dickkopf antikoerper, dkk1.S antikoerper

Hintergrund:

Synonyms: SK, DKK-1, Dickkopf-related protein 1, Dickkopf-1, hDkk-1, DKK1, UNQ492/PRO18

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gen-ID: 22943

UniProt: O94907

Pathways: WNT Signalweg, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation