DKK1 Antikörper

Produktnummer ABIN969085

Dieser Maus Monoklonal Antikörper detektiert spezifisch DKK1 in ELISA. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für DKK1 Antikörper (ABIN969085)

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DKK1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 2H2

Produktdetails anti-DKK1 Antikörper

Verwendungszweck: DKK1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of DKK1 expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-DKK1 Antikörper (ABIN969085)

Yamamoto, Sakane, Yamamoto, Michiue, Kikuchi: "Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling." in: Developmental cell, Vol. 15, Issue 1, pp. 37-48, (2008) (PubMed).

Qiao, Xu, Zhao, Ye, Zhang: "Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling." in: Cancer letters, Vol. 269, Issue 1, pp. 67-77, (2008) (PubMed).

Details zu DKK1

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Andere Bezeichnung: DKK1

Hintergrund: DKK1: dickkopf homolog 1 (Xenopus laevis), also known as SK. Entrez Protein NP_036374. DKK1 is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Molekulargewicht: 28.7 kDa

Gen-ID: 22943

UniProt: O94907

Pathways: WNT Signalweg, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation