CYLD Antikörper (N-Term)
Kurzübersicht für CYLD Antikörper (N-Term) (ABIN6756791)
Target
Alle CYLD Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- N-Term
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Spezifität
- Human CYLD
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Aufreinigung
- Protein A purified
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Immunogen
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A recombinant protein fragment from the N-terminal region of human CYLD.
Type of Immunogen: Recombinant protein -
Isotyp
- IgG
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Applikationshinweise
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Approved: WB (2 - 5 μg/mL)
Usage: CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling. -
Kommentare
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Target Species of Antibody: Human
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- Lot specific
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Buffer
- PBS, pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- avoid freeze thaw cycles
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze-thaw cycles.
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- CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
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Andere Bezeichnung
- CYLD
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Hintergrund
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Name/Gene ID: CYLD
Synonyms: CYLD, CDMT, Deubiquitinating enzyme CYLD, CYLDI, EAC, HSPC057, MFT1, MFT, SBS, TEM, BRSS, Ubiquitin thiolesterase CYLD, USPL2, CYLD1, KIAA0849, Ubiquitin thioesterase CYLD -
Gen-ID
- 1540
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Pathways
- Apoptose, Activation of Innate immune Response
Target
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