SFRP1 Antikörper (AA 201-314)

Produktnummer ABIN674694

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-SFRP1 Antikörper (ABIN674694) detektiert spezifisch SFRP1 in WB, ELISA, IHC (p), IF (cc), IF (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für SFRP1 Antikörper (AA 201-314) (ABIN674694)

Target: SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SFRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SFRP1 Antikörper

Bindungsspezifität: AA 201-314

Kreuzreaktivität: Maus, Ratte

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SFRP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SFRP1 Antikörper (ABIN674694)

Wang, Xie, Xie, Wan, Ma, Qi, Yang: "MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma." in: Neuroreport, Vol. 26, Issue 12, pp. 695-702, (2015) (PubMed).

Details zu SFRP1

Target: SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))

Andere Bezeichnung: SFRP1

Hintergrund:

Synonyms: FRP, FRP1, FrzA, FRP-1, SARP2, Secreted frizzled-related protein 1, sFRP-1, Secreted apoptosis-related protein 2, SARP-2, SFRP1

Background: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Gen-ID: 6422

UniProt: Q8N474

Pathways: WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of fat Cell Differentiation