ABL2 Antikörper (AA 935-1050) (Biotin)

Produktnummer ABIN673706

Der Kaninchen Polyklonal Anti-ABL2-Antikörper wurde für WB, ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, ABL2 in Proben von Human zu detektieren.

Kurzübersicht für ABL2 Antikörper (AA 935-1050) (Biotin) (ABIN673706)

Target: ABL2

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ABL2 Antikörper (Biotin)

Bindungsspezifität: AA 935-1050

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ABL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ABL2

Target: ABL2

Andere Bezeichnung: ABL2

Hintergrund:

Synonyms: Abelson murine leukemia viral oncogene homolog 2, Abelson related gene protein, Tyrosine kinase ARG, ABLL,ARG,Tyrosine protein kinase ABL2, v abl Abelson murine leukemia viral oncogene homolog 2, ABL2_HUMAN, Abelson tyrosine-protein kinase 2, Tyrosine-protein kinase ARG.

Background: ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. It is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments.

Gen-ID: 27