NOTCH3 Antikörper (PE)

Produktnummer ABIN6722241

Dieses Anti-NOTCH3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von NOTCH3 in FACS. Geeignet für Human.

Kurzübersicht für NOTCH3 Antikörper (PE) (ABIN6722241)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NOTCH3 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: MHN3-21

Produktdetails anti-NOTCH3 Antikörper (PE)

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Details zu NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Andere Bezeichnung: Notch3

Hintergrund:

Synonyms: NOTCH3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain

Background: The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.

Gen-ID: 4854

UniProt: Q9UM47

Pathways: Notch Signalweg