CDK4 Antikörper (AA 241-303) (HRP)
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- Target Alle CDK4 Antikörper anzeigen
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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Bindungsspezifität
- AA 241-303
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Reaktivität
- Human, Maus, Ratte, Schaf
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CDK4 Antikörper ist konjugiert mit HRP
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Human, Maus, Ratte, Schaf
- Homologie
- Cow,Pig
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human CDK4
- Isotyp
- IgG
- Top Product
- Discover our top product CDK4 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
- Andere Bezeichnung
- CDK4 (CDK4 Produkte)
- Synonyme
- zgc:153726 antikoerper, CMM3 antikoerper, PSK-J3 antikoerper, Crk3 antikoerper, 8-6 antikoerper, CDK4 antikoerper, CDK4/6 antikoerper, CG5072 antikoerper, Cdk4/6 antikoerper, DmCdk4 antikoerper, Dmel\\CG5072 antikoerper, Pk53C antikoerper, Pk?7 antikoerper, cdk antikoerper, cdk4 antikoerper, cdk4/6 antikoerper, dCdk4 antikoerper, l(2)05428 antikoerper, l(2)0671 antikoerper, l(2)k06503 antikoerper, l(2)s4639 antikoerper, l(2)sh0671 antikoerper, xcdk4 antikoerper, cyclin-dependent kinase 4 antikoerper, cyclin dependent kinase 4 antikoerper, Cyclin-dependent kinase 4 antikoerper, cyclin-dependent kinase 4 L homeolog antikoerper, cdk4 antikoerper, CDK4 antikoerper, Cdk4 antikoerper, cdk4.L antikoerper
- Hintergrund
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Synonyms: CMM3, PSK-J3, Cyclin-dependent kinase 4, Cell division protein kinase 4, CDK4
Background: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Gen-ID
- 1019
- UniProt
- P11802
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size
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