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Angiotensin II Antikörper

Ang II Reaktivität: Human IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN670521
  • Target Alle Angiotensin II (Ang II) Antikörper anzeigen
    Angiotensin II (Ang II)
    Reaktivität
    • 30
    • 9
    • 7
    • 3
    Human
    Wirt
    • 30
    • 4
    Kaninchen
    Klonalität
    • 28
    • 5
    • 1
    Polyklonal
    Konjugat
    • 14
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Angiotensin II Antikörper ist unkonjugiert
    Applikation
    • 12
    • 11
    • 11
    • 9
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    The immunogen used generate this antibody is DRVYIHPF, corresponding to amino acids 34-41 of human Angiotensinogen.
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    MAP conjugated synthetic peptide derived from human Angiotensin II
    Isotyp
    IgG
  • Applikationshinweise
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, (2016) (PubMed).

    Anand, Yiangou, Sinisi, Fox, MacQuillan, Quick, Korchev, Bountra, McCarthy, Anand: "Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies." in: Molecular pain, Vol. 11, pp. 38, (2015) (PubMed).

  • Target
    Angiotensin II (Ang II)
    Andere Bezeichnung
    Angiotensin II (Ang II Produkte)
    Synonyme
    ANHU antikoerper, SERPINA8 antikoerper, ANRT antikoerper, Ang antikoerper, AngII antikoerper, PAT antikoerper, AI265500 antikoerper, AngI antikoerper, Aogen antikoerper, Serpina8 antikoerper, angiotensinogen antikoerper, angiotensinogen (serpin peptidase inhibitor, clade A, member 8) antikoerper, AGT antikoerper, Agt antikoerper
    Hintergrund

    Synonyms: Alpha 1 antiproteinase, antitrypsin, Ang II, ANG III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, Angiotensinogen serpin peptidase inhibitor, clade A member 8, ANHU, Pre angiotensinogen, Serine or cysteine proteinase inhibitor, Serpin A8, SERPINA8, AT-2, AT-II, ANGT_HUMAN.

    Background: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

    Gen-ID
    183
    Pathways
    JAK-STAT Signalweg, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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