Angiotensin II Antikörper (Ang II)

Details for Product anti-Ang II Antibody No. ABIN670521, Anbieter: Anmelden zum Anzeigen
Antigen
  • ANHU
  • SERPINA8
  • ANRT
  • Ang
  • AngII
  • PAT
  • AI265500
  • AngI
  • Aogen
  • Serpina8
  • angiotensinogen
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • AGT
  • Agt
Reaktivität
Human
48
6
6
3
Wirt
Kaninchen
41
8
Klonalität
Polyklonal
Konjugat
Dieser Angiotensin II Antikörper ist unkonjugiert
6
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
21
12
10
8
6
4
4
3
3
2
2
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen MAP conjugated synthetic peptide derived from human Angiotensin II
Isotyp IgG
Spezifität The immunogen used generate this antibody is DRVYIHPF, corresponding to amino acids 34-41 of human Angiotensinogen.
Reinigung Purified by Protein A.
Andere Bezeichnung Angiotensin II (Ang II Antibody Abstract)
Hintergrund

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Subcellular location: Secreted

Synonyms: Alpha 1 antiproteinase, antitrypsin, Ang II, ANG III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, Angiotensinogen serpin peptidase inhibitor, clade A member 8, ANHU, Pre angiotensinogen, Serine or cysteine proteinase inhibitor, Serpin A8, SERPINA8, AT-2, AT-II, ANGT_HUMAN.

Gen-ID 183
Pathways JAK-STAT Signalweg, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Applikationshinweise IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
ELISA image for anti-Angiotensin II (Ang II) antibody (ABIN670521) anti-Angiotensin II (Ang II) antibody
Immunohistochemistry (IHC) image for anti-Angiotensin II (Ang II) antibody (ABIN670521) Formalin-fixed and paraffin embedded rat pancreas tissue labeled with Anti-Angiotensi...
Produkt verwendet in: Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, 2016 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Dog (Canine)). Weitere Details: Sample: Lung and heart tissues

Anand, Yiangou, Sinisi, Fox, MacQuillan, Quick, Korchev, Bountra, McCarthy, Anand: "Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies." in: Molecular pain, Vol. 11, pp. 38, 2015 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Frozen Sections) (IHC (fro)) (Probematerial (Species): Human). Weitere Details: Sample: drg neruons and nerve tissue

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