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Angiotensin II Antikörper

Dieses Anti-Angiotensin II-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Angiotensin II in IF (p) und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
Produktnummer ABIN670521

Kurzübersicht für Angiotensin II Antikörper (ABIN670521)

Target

Alle Angiotensin II (Ang II) Antikörper anzeigen
Angiotensin II (Ang II)

Reaktivität

  • 35
  • 10
  • 8
  • 3
Human

Wirt

  • 36
  • 7
Kaninchen

Klonalität

  • 34
  • 8
  • 1
Polyklonal

Konjugat

  • 21
  • 6
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Angiotensin II Antikörper ist unkonjugiert

Applikation

  • 19
  • 19
  • 13
  • 12
  • 12
  • 8
  • 6
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Spezifität

    The immunogen used generate this antibody is DRVYIHPF, corresponding to amino acids 34-41 of human Angiotensinogen.

    Kreuzreaktivität

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    MAP conjugated synthetic peptide derived from human Angiotensin II

    Isotyp

    IgG
  • Applikationshinweise

    IHC-P 1:100-500
    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, (2016) (PubMed).

    Anand, Yiangou, Sinisi, Fox, MacQuillan, Quick, Korchev, Bountra, McCarthy, Anand: "Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies." in: Molecular pain, Vol. 11, pp. 38, (2015) (PubMed).

  • Target

    Angiotensin II (Ang II)

    Andere Bezeichnung

    Angiotensin II

    Hintergrund

    Synonyms: Alpha 1 antiproteinase, antitrypsin, Ang II, ANG III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, Angiotensinogen serpin peptidase inhibitor, clade A member 8, ANHU, Pre angiotensinogen, Serine or cysteine proteinase inhibitor, Serpin A8, SERPINA8, AT-2, AT-II, ANGT_HUMAN.

    Background: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

    Gen-ID

    183

    Pathways

    JAK-STAT Signalweg, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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