tau Antikörper (PE)

Produktnummer ABIN6698783

Der Kaninchen Polyklonal Anti-tau-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, tau in Proben von Human und Maus zu detektieren.

Kurzübersicht für tau Antikörper (PE) (ABIN6698783)

Target: tau (tau Protein)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser tau Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-tau Antikörper (PE)

Spezifität: Detects ~45.8kda.

Aufreinigung: Protein A Purified

Immunogen: Synthetic peptide from the full length of Human Tau

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:1000 dilution of ABIN6698783 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Details zu tau

Target: tau (tau Protein)

Andere Bezeichnung: Tau

Hintergrund: Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).

Gen-ID: 4137

UniProt: P10636