MAPT Antikörper (pSer416)

Produktnummer ABIN6658211

Hersteller Produkt- Nr.: 612-401-e42

Dieses Anti-MAPT-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAPT in WB und IHC. Geeignet für Ratte.

Kurzübersicht für MAPT Antikörper (pSer416) (ABIN6658211)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MAPT Antikörper

Bindungsspezifität: pSer416

Hersteller Produkt- Nr.: 612-401-e42

Hersteller: Rockland

Verwendungszweck: Tau phospho S416 Antibody

Kreuzreaktivität (Details): Anti-Tau pS416 antibody is directed against rat Tau.

Aufreinigung: Tau pS416 antibodies was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogen: Anti-Tau pS416 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 of the Tau protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-Tau pS416 (Rabbit) antibody is tested for use in Western Blot and IHC. Expect bands approximately 59, 65, 68 kDa in size corresponding to tau proteins phosphorylated at Ser416 in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: Mapt

Hintergrund:

Synonyms: Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

Background: Tau pS416 Antibody detects Tau, which s a key microtubule-associated protein that plays an important role in the formation of microtubules in axons. Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing. Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer's disease (AD), Pick's disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain. Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II. Anti-Tau pS416 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: MAPT

Gen-ID: 69329

UniProt: P19332

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size