KDM1B Antikörper (Internal Region, N-Term)

Produktnummer ABIN6655594

Hersteller Produkt- Nr.: 100-401-w43

Der Kaninchen Polyklonal Anti-KDM1B-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, KDM1B in Proben von Human zu detektieren.

Kurzübersicht für KDM1B Antikörper (Internal Region, N-Term) (ABIN6655594)

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM1B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-KDM1B Antikörper

Bindungsspezifität: Internal Region, N-Term

Hersteller Produkt- Nr.: 100-401-w43

Hersteller: Rockland

Verwendungszweck: KDM1B Antibody

Kreuzreaktivität (Details): Cross reactivity with KDM1B from other species not tested.

Aufreinigung: Anti-KDM1B Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Sterilität: Sterile filtered

Immunogen: Anti-KDM1B Antibody was produced in rabbits by repeated immunizations with two different synthetic peptides containing a sequence from the N-terminus and internal region of the human KDM1B protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:500

Kommentare:

Anti-KDM1B Antibody has been tested by ELISA. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu KDM1B

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Andere Bezeichnung: KDM1B

Hintergrund:

Synonyms: Lysine-specific histone demethylase 1B, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2, AOF1, C6orf193, LSD2

Background: KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Anti-KDM1B is ideal for research in Epigenetics and Gene Expression.

Gene Name: KDM1B

Gen-ID: 221656

NCBI Accession: NP_694587

UniProt: Q8NB78

Pathways: Warburg Effekt