GREM1 Antikörper

Produktnummer ABIN6655147

Hersteller Produkt- Nr.: 200-401-h77

Der Kaninchen Polyklonal Anti-GREM1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, GREM1 in Proben von Human zu detektieren.

Kurzübersicht für GREM1 Antikörper (ABIN6655147)

Target: GREM1 (Gremlin 1 (GREM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GREM1 Antikörper

Hersteller Produkt- Nr.: 200-401-h77

Hersteller: Rockland

Verwendungszweck: Gremlin Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with Anti-Gremlin from Human, Rat and Mouse based on 100 % homology with the immunizing sequence.

Aufreinigung: Anti-Gremlin Antibody was purified by Protein G chromatography.

Immunogen: Gremlin Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to the internal amino acid sequences within the Gremlin-1 human protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 2.5-10 μg/mL (paraffin)

Western_Blot_Dilution: 1:500-1:1000

Kommentare:

Anti-Gremlin Antibody is tested for use in IHC (cryosections) and IHC-P. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Andere Bezeichnung: Gremlin

Hintergrund:

Synonyms: CKTSF1B1, DAND2, DRM, Gremlin-1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1, BMP antagonist 1, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2

Background: Anti-Gremlin Antibody detects human Gremlin. In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Gremlin (CKTSF1B1) is localized on chromosome 15q13--> q15. DRM-specific mRNA is expressed in different tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of Gremlin is associated with tumor progression, and support the hypothesis that Gremlin may play an important role during both neuroembryological development and carcinogenesis. Anti-Gremlin Antibody is ideal for investigators involved in NFkappaB, signaling, and cell cycle protein research.

Gene Name: GREM1

Gen-ID: 26585

NCBI Accession: NP_001178252

UniProt: O60565

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location