GFAP Antikörper

Produktnummer ABIN6655052

Hersteller Produkt- Nr.: 100-401-d60

Dieses Anti-GFAP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GFAP in WB, IHC und FM. Geeignet für Rind (Kuh). Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für GFAP Antikörper (ABIN6655052)

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reaktivität: Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Produktdetails anti-GFAP Antikörper

Hersteller Produkt- Nr.: 100-401-d60

Hersteller: Rockland

Verwendungszweck: Glial Fibrillary Acidic Protein (GFAP) Antibody

Kreuzreaktivität (Details): The antibody is directed against bovine glial fibrillary acidic proteins.

Aufreinigung: Anti-GFAP antibody was prepared from monospecifc neat serum.

Immunogen: Anti-GFAP Antibody was produced in rabbit by repeated immunizations with recombinant and purified bovine glial fibrillary acidic protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IF_Microscopy_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-Glial Fibrillary Acidic Protein (Rabbit) antibody has been tested by western blot, ICC, and IHC and is suitable for use in IF. Anti-Glial Fibrillary Acidic Protein antibodies are specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-GFAP Antikörper (ABIN6655052)

Qin, Buckley, Li, Liu, Fox, Meares, Yu, Yan, Harms, Li, Standaert, Benveniste: "Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 36, Issue 18, pp. 5144-59, (2017) (PubMed).

Details zu GFAP

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Hintergrund:

Synonyms: gfapl, DKFZp459C0729, MGC139638, FLJ45472, AI836096, cb345.

Background: Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers. Therefore, GFAP antibody is ideal for investigators involved in neuropathologic diseases and more generally in Neuroscience.

Gene Name: GFAP

Gen-ID: 281189

UniProt: Q28115