GFAP Antikörper (Glial Fibrillary Acidic Protein) (AA 93-432)

Details for Product anti-GFAP Antibody No. ABIN3043832, Anbieter: Anmelden zum Anzeigen
Antigen
  • GFAP
  • AI836096
  • cb345
  • etID36982.3
  • gfapl
  • wu:fb34h11
  • wu:fk42c12
  • xx:af506734
  • zgc:110485
  • glial fibrillary acidic protein
  • GFAP
  • LOC100136168
  • gfap
  • Gfap
Epitop
AA 93-432
69
57
32
32
28
16
15
9
6
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3
2
2
2
2
2
2
1
1
1
1
1
1
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1
Reaktivität
Human, Maus, Ratte (Rattus)
732
416
400
199
185
140
102
36
33
32
25
24
21
21
12
7
7
6
3
3
2
2
1
1
1
1
1
1
1
Wirt
Kaninchen
465
313
26
23
4
3
2
Klonalität
Polyklonal
Konjugat
Dieser GFAP Antikörper ist unkonjugiert
34
24
24
17
16
11
9
9
9
8
5
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5
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4
2
2
2
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
626
338
268
266
236
222
140
89
73
53
16
15
13
12
9
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3
1
1
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1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Verwendungszweck Rabbit IgG polyclonal antibody for Glial fibrillary acidic protein(GFAP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Immunogen E.coli-derived human GFAP recombinant protein (Position: Q93-M432). Human GFAP shares 94% amino acid (aa) sequence identity with both mouse and rat GFAP.
Isotyp IgG
Kreuzreaktivität (Details) No cross reactivity with other proteins.
Produktmerkmale Rabbit IgG polyclonal antibody for Glial fibrillary acidic protein(GFAP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: glial fibrillary acidic protein
Protein Name: Glial fibrillary acidic protein
Reinigung Immunogen affinity purified.
Andere Bezeichnung GFAP (GFAP Antibody Abstract)
Hintergrund Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is an intermediate filament(IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes, and ependymal cells. It is mapped to 17q21.31. GFAP is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell's cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells. This gene has been shown to play a role in mitosis by adjusting the filament network present in the cell. GFAP is necessary for many critical roles in the CNS. What's more, GFAP also plays a role in astrocyte-neuron interactions as well as cell-cell communication.

Synonyms: Astrocyte antibody|FLJ42474 antibody|FLJ45472 antibody|GFAP antibody|GFAP_HUMAN antibody|Glial Fibrillary Acidic Protein antibody|Intermediate filament protein antibody
Gen-ID 2670
UniProt P14136
Applikationshinweise WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for GFAP is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Kommentare

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Konzentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Glial Fibrillary Acidic Protein (GFAP) (AA 93-432) antibody (ABIN3043832) Anti-GFAP Picoband antibody, IHC(P): Human meningioma Tissue
Immunohistochemistry (IHC) image for anti-Glial Fibrillary Acidic Protein (GFAP) (AA 93-432) antibody (ABIN3043832) Anti-GFAP Picoband antibody, IHC(P): Rat Brain Tissue
Western Blotting (WB) image for anti-Glial Fibrillary Acidic Protein (GFAP) (AA 93-432) antibody (ABIN3043832) Observed bind size: 49KD
Immunohistochemistry (IHC) image for anti-Glial Fibrillary Acidic Protein (GFAP) (AA 93-432) antibody (ABIN3043832) Anti-GFAP Picoband antibody, IHC(P): Mouse Brain Tissue
Produkt verwendet in: Lu, Yuan, Ou, Cai, Wang, Sun, Zhang: "Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro." in: Neural regeneration research, Vol. 7, Issue 16, pp. 1205-12, 2015 (PubMed).

Liu, Zhang, Zhao, Cui, Cao, Guo: "Effects of hypothermia on S100B and glial fibrillary acidic protein in asphyxia rats after cardiopulmonary resuscitation." in: Cell biochemistry and biophysics, Vol. 71, Issue 1, pp. 401-6, 2015 (PubMed).

Liu, Cheng, Wang, Zhan, Xiong, Zhao: "Bone marrow-derived mesenchymal stem cells differentiate into nerve-like cells in vitro after transfection with brain-derived neurotrophic factor gene." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 3, pp. 319-27, 2015 (PubMed).

Yuan, Chen, Wu, Chen, Hu, Zhang, Wang, Zhu: "The regulatory mechanism of neurogenesis by IGF-1 in adult mice." in: Molecular neurobiology, Vol. 51, Issue 2, pp. 512-22, 2015 (PubMed).

Lan, Zheng, Yang, Ji, Fan, Zeng: "Peroxisome proliferator-activated receptor-? agonist pioglitazone ameliorates white matter lesion and cognitive impairment in hypertensive rats." in: CNS neuroscience & therapeutics, Vol. 21, Issue 5, pp. 410-6, 2015 (PubMed).

Zhao, Yuan, Chen, Jiang, Liao, Wang, Zhang, Ohtsu, Hu, Chen: "Histamine promotes locomotion recovery after spinal cord hemisection via inhibiting astrocytic scar formation." in: CNS neuroscience & therapeutics, Vol. 21, Issue 5, pp. 454-62, 2015 (PubMed).

Xu, Yang, Xiong, Gu, He, Hu, Xiao, Chen, Wang: "Increased expression of receptor for activated C kinase 1 in temporal lobe epilepsy." in: Journal of neurochemistry, Vol. 133, Issue 1, pp. 134-43, 2015 (PubMed).

Zhang, Li, Zeng, Chen, Fang, Huang: "Long-term tracing of the BrdU label-retaining cells in adult rat brain." in: Neuroscience letters, Vol. 591, pp. 30-4, 2015 (PubMed).

Zhu, Dong, Shen, Bai, Zhang, Lv, Chao, Yao: "NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress." in: Brain research bulletin, Vol. 114, pp. 70-8, 2015 (PubMed).

Ge, Lei, Wang, Zhang, Han, Chen, Li, Jiang, Kang, Zhang: "miR-21 improves the neurological outcome after traumatic brain injury in rats." in: Scientific reports, Vol. 4, pp. 6718, 2014 (PubMed).

Hu, Wang, Zhang, Jiang, Zhang, Zhang, Lei, Park, Fang, Chen: "Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces." in: Biomaterials, Vol. 35, Issue 26, pp. 7386-97, 2014 (PubMed).

Sun, Cong, Liu, Jin, Si, Wang, Cai, Che, Tang, Wang, Li, Zhang: "Schisandrin A and B affect subventricular zone neurogenesis in mouse." in: European journal of pharmacology, Vol. 740, pp. 552-9, 2014 (PubMed).

Bai, Xu, Xu, Li, Qin: "Inhibition of Src phosphorylation reduces damage to the blood-brain barrier following transient focal cerebral ischemia in rats." in: International journal of molecular medicine, Vol. 34, Issue 6, pp. 1473-82, 2014 (PubMed).

Zhou, Cheng, Rao, Li, Duan: "Poly(3,4-ethylenedioxythiophene)/multiwall carbon nanotube composite coatings for improving the stability of microelectrodes in neural prostheses applications." in: Acta biomaterialia, Vol. 9, Issue 5, pp. 6439-49, 2013 (PubMed).

Wang, Li, Wang, Mei, Liu, Shen, Xiao: "Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit." in: Neuroscience bulletin, Vol. 29, Issue 2, pp. 251-9, 2013 (PubMed).

Zhang, Xie, Wan, Ye, Guo, Lei: "Identification of U251 glioma stem cells and their heterogeneous stem-like phenotypes." in: Oncology letters, Vol. 6, Issue 6, pp. 1649-1655, 2013 (PubMed).

Liu, Zhou, Li, Liu, Huang, Zhou: "Selenoprotein S expression in the rat brain following focal cerebral ischemia." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 34, Issue 9, pp. 1671-8, 2013 (PubMed).

Chen, Chen, Chen, Hu, Gao, Xie, Wang, Yin, Li, Wang: "ADAM17 promotes U87 glioblastoma stem cell migration and invasion." in: Brain research, Vol. 1538, pp. 151-8, 2013 (PubMed).

Chen, Pan, Georgakilas, Chen, Hu, Yang, Tian, Xia, Zhang, Cai, Ge, Yu, Zhuang: "Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression." in: Cancer letters, Vol. 336, Issue 2, pp. 281-9, 2013 (PubMed).

Yu, Guo, Liu, Ouyang, He, Burnstock, Yuan, Xiang: "Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampus after transient global cerebral ischemia." in: Purinergic signalling, Vol. 9, Issue 4, pp. 663-75, 2013 (PubMed).

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