CD40 Ligand Antikörper

Produktnummer ABIN6651981

Dieser Hamster Monoklonal Antikörper detektiert spezifisch CD40 Ligand in FACS und IHC (p). Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für CD40 Ligand Antikörper (ABIN6651981)

Target: CD40 Ligand (CD40LG)

Reaktivität: Maus

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser CD40 Ligand Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MAB0712

Produktdetails anti-CD40 Ligand Antikörper

Spezifität: This antibody detects Mouse CD40 Ligand. Other species not tested. Species: Mouse.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Mouse Th1 cells.

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 1/100-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/300.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS Stabilizers: None

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD40 Ligand

Target: CD40 Ligand (CD40LG)

Andere Bezeichnung: cd154,cd40l

Hintergrund: CD40 ligand (CD40L), also known as CD154, TNFSF5, TRAP or gp39, is a 260 amino acid type II transmembrane glycoprotein belonging to the TNF family. Murine CD40L consists of a 22 aa cytoplasmic domain, a 24 aa transmembrane domain, and 214 aa extracellular domain bearing a single glycosylation site. CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including NK cells, mast cells, basophils and eosinophils. Murine CD40L shares 78 % amino acid sequence identity with human CD40L. Native bioactive soluble CD40L exists. Soluble human trimeric CD40L secreted by stimulated T cells has been shown to be generated by proteolysis in the microsomes. Both membrane bound and soluble CD40L induce similar effects on B cells.

UniProt: P27548

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints