MME Antikörper (AA 272-300)

Produktnummer ABIN659195

Der Maus Monoklonal anti-MME Antikörper wird verwendet zum Nachweis von MME in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für MME Antikörper (AA 272-300) (ABIN659195)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MME Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 307CT12-12-5

Produktdetails anti-MME Antikörper

Bindungsspezifität: AA 272-300

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This MME/CD10 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from human MME/CD10.

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB: 1:1000~4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: MME/CD10 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Details zu MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: MME/CD10

Substanzklasse: Chemical

Hintergrund: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq].

Molekulargewicht: 85514

Gen-ID: 4311

NCBI Accession: NP_000893, NP_009218, NP_009219, NP_009220

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration