Perforin 1 Antikörper (AA 451-500)

Produktnummer ABIN6579662

Der Kaninchen Polyklonal anti-Perforin 1 Antikörper (ABIN6579662) detektiert spezifisch Perforin 1 in WB, IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Perforin 1 Antikörper (AA 451-500) (ABIN6579662)

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Perforin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Perforin 1 Antikörper

Bindungsspezifität: AA 451-500

Verwendungszweck: Perforin 1 Antibody

Spezifität: Perforin 1 Polyclonal Antibody detects endogenous levels of Perforin 1

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000, IHC 1:50-200, ELISA 1:10000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Andere Bezeichnung: PRF1

Hintergrund:

Synonyms: Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)

Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

Gene Name: PRF1

Protein Name: Perforin 1

Molekulargewicht: 61 kDa

Gen-ID: 5551

OMIM: 170280

UniProt: P14222

Pathways: Apoptose, Caspase Kaskade in der Apoptose