CDK4 Antikörper (AA 1-50)

Produktnummer ABIN6579321

Der Kaninchen Polyklonal anti-CDK4 Antikörper (ABIN6579321) detektiert spezifisch CDK4 in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für CDK4 Antikörper (AA 1-50) (ABIN6579321)

Target: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-CDK4 Antikörper

Bindungsspezifität: AA 1-50

Verwendungszweck: Cdk4 Antibody

Spezifität: Cdk4 Polyclonal Antibody detects endogenous levels of Cdk4 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human CDK4. AA range:1-50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:50-200 WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CDK4

Target: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Andere Bezeichnung: CDK4

Hintergrund:

Synonyms: CDK4, Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3

Background: cyclin dependent kinase 4(CDK4) Homo sapiens The protein encoded byThis gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],

Gene Name: CDK4

Protein Name: Cyclin-dependent kinase 4

Molekulargewicht: 33 kDa

Gen-ID: 1019

OMIM: 123829

UniProt: P11802

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size