Synonyms: AF 1P,AF 1p protein,AF1P,ALL1 fused gene from chromosome 1,Epidermal growth factor receptor pathway substrate 15,Epidermal growth factor receptor substrate 15,EPS 15,MLLT 5,MLLT5,Protein Eps 15,Protein Eps15
Background: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.