DUSP4 Antikörper

Produktnummer ABIN6569333

Der Kaninchen Polyklonal Anti-DUSP4-Antikörper wurde für WB validiert. Er ist geeignet, DUSP4 in Proben von Human und Affe zu detektieren.

Kurzübersicht für DUSP4 Antikörper (ABIN6569333)

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DUSP4 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human DUSP4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu DUSP4

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Andere Bezeichnung: MKP-2

Hintergrund:

Synonyms: Dual specificity phosphatase 4,Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,DUS4,DUSP 4,Dusp4,HVH 2,HVH2,MAP kinase phosphatase 2,Mitogen activated protein kinase phosphatase 2,Mitogen-activated protein kinase phosphatase 2,MKP 2,MKP-2,MKP2,Serine/threonine specific protein phosphatase,TYP,Typ1,VH 2,VH1 homologous phosphatase 2,VH2

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Molekulargewicht:

Observed_MW: 43kDa

Calculated_MW: 32kDa/42kDa

Gen-ID: 1846

UniProt: Q13115

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades