Minichromosome Maintenance Complex Component 6 (MCM6) Antikörper

Details zu Produkt Nr. ABIN6569004
Target
Reaktivität
Human, Maus, Ratte
57
21
18
10
7
7
7
4
2
1
1
Wirt
Kaninchen
48
7
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
48
36
26
13
10
3
3
2
2
2
2
1
1
1
Optionen
Immunogen Recombinant protein of human MCM6
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MCM6 (MCM6 Antibody Abstract)
Hintergrund

Synonyms: DNA replication licensing factor MCM6,MCG40308,Mcm6,MCM6 minichromosome maintenance deficient 6 (MIS5 homolog,S. pombe),MCM6 minichromosome maintenance deficient 6,MCM6,Minichromosome maintenance complex component 6,Minichromosome maintenance deficient (mis5 S. pombe) 6,Minichromosome maintenance deficient 6 homolog,Minichromosome maintenance protein 6,Mis5,MIS5 homolog,p105MCM

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.

Molekulargewicht

Observed_MW: 110kDa

Calculated_MW: 92kDa

Gen-ID 4175
UniProt Q14566
Pathways DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN6569004) Immunofluorescence analysis of U2OS cells using MCM6 antibody.
Image no. 2 for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN6569004) Western blot analysis of extracts of various cell lines, using MCM6 antibody.
Image no. 3 for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN6569004) Immunohistochemistry of paraffin-embedded human lung cancer using MCM6 antibody.