Synonyms: Cysteine rich protein TTG 2,Cysteine rich protein TTG2,Cysteine-rich protein TTG-2,LIM domain only 2 (rhombotin like 1),LIM domain only 2,LIM domain only protein 2,LMO 2,LMO-2,lmo2,RBTN 2,RBTN L1,RBTN2,RBTN2,RBTNL 1,RBTNL1,RHOM 2,RHOM2,Rhombotin 2,Rhombotin like 1,Rhombotin-2,Rhombotin2,T cell translocation gene 2,T cell translocation protein 2,T-cell translocation protein 2,TTG 2,TTG2
Background: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.