Synonyms: Beta trace protein,Beta-trace protein,Cerebrin 28,Cerebrin-28,glutathione independent PGD synthase,Glutathione independent PGD synthetase,Glutathione-independent PGD synthase,L PGDS,Lipocalin type prostaglandin D synthase,Lipocalin-type prostaglandin-D synthase,LPGDS,PDS,PGD2,PGD2 synthase,PGDS,PGDS2,prostaglandin D synthase,prostaglandin D2 synthase (21 kDa,brain),prostaglandin D2 synthase (brain),prostaglandin D2 synthase 21 kDa (brain),Prostaglandin D2 synthase,prostaglandin H2 D isomerase,Prostaglandin-D2 synthase,Prostaglandin-H2 D-isomerase,PTGDS,PTGDS,RP23-47P18.11-006
Background: The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.